May 1977

Platelet Monoamine Oxidase in Early Childhood Autism

Author Affiliations

From the Departments of Pediatrics (Drs Cohen and Young), Psychiatry (Drs Cohen and Young), Psychology (Dr Cohen), and Anesthesiology (Dr Roth), Yale University School of Medicine, and the Child Study Center, New Haven, Conn. Dr Roth is now with the Department of Pharmacology and Therapeutics, School of Medicine and Dentistry, State University of New York at Buffalo.

Arch Gen Psychiatry. 1977;34(5):534-537. doi:10.1001/archpsyc.1977.01770170044003

• Platelet monoamine oxidase (MAO) activity was studied in 31 individuals suffering from early childhood autism and was not significantly different from that found in normal children or adults. In the autistic children, MAO activity decreased with age, and there was a trend toward greater platelet MAO activity in prepubertal and pubertal male autistic children relative to normal male children. Total platelet counts were not elevated in autistic children.