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June 1977

Linkage Between an X-Chromosome Marker (Deutan Color Blindness) and Bipolar Affective IllnessOccurrence in the Family of a Lithium Carbonate-Responsive Schizo-affective Proband

Author Affiliations

From the Department of Psychiatry, Albert Einstein College of Medicine, New York.

Arch Gen Psychiatry. 1977;34(6):721-725. doi:10.1001/archpsyc.1977.01770180107010

• Studies with X-chromosome markers in mental illness have been limited to the diagnostic concept of primary affective disorders. The present study is the first to our knowledge to demonstrate statistically measurable linkage between color blindness and manic-depressive illness in a family identified by a schizo-affective proband.

Linkage data and lithium carbonate response in the proband suggest that the schizophreniform-affective spectrum in members of the pedigree may reflect a genetically distinct disorder. The use of a genetic marker as a heuristic diagnostic criterion in a subgroup of heredofamilial psychoses with unclear diagnostic boundaries is proposed.