July 1977

Abnormal-Pursuit Eye Movements in SchizophreniaEvidence for a Genetic Indicator

Author Affiliations

From the Departments of Psychiatry (Drs Holzman and Levy) and Statistics (Dr Haberman), and the Franklin McLean Memorial Research Institute (Mr Yasillo), University of Chicago; the Department of Psychiatry, University of Oslo (Dr Kringlen); and the Department of Otolaryngology, Johns Hopkins Hospital, Baltimore (Dr Proctor).

Arch Gen Psychiatry. 1977;34(7):802-805. doi:10.1001/archpsyc.1977.01770190064005

• Disordered smooth-pursuit eye movements occur in a high percentage of schizophrenic patients and their first-degree relatives. A test of the hypothesis that these disorders represent a genetic indicator of schizophrenia was undertaken by testing pursuit eye movements in a sample of monozygotic and dizygotic twins discordant for clinical schizophrenia. Deviant eye tracking is significantly concordant within monozygotic twin pairs, and less so within dizygotic twin pairs discordant for schizophrenia. A genetic interpretation is consistent with these results.