• A case of a folate-responsive psychosis that was associated with a defect in N5.10-methylenetetrahydrofolate reductase (methylene reductase) suggested the need to examine whether abnormally low activity of this enzyme might be of etiological importance in schizophrenia. We now report that there were no statistically significant differences in the platelet methylene reductase activity of chronic schizophrenics, compared with either hospitalized or nonhospitalized age-matched control subjects. Although it is possible that a larger survey might reveal a subpopulation of schizophrenics who are characterized by abnormal methylene reductase activity, this study suggests that chronic schizophrenia is not generally associated with such changes.
Berger PA, Elliott GR, Erdelyi E, Watson SJ, Wyatt RJ, Barchas JD. Platelet Methylene Reductase Activity in Schizophrenia. Arch Gen Psychiatry. 1977;34(7):808-809. doi:10.1001/archpsyc.1977.01770190070006