September 1977

Water Intoxication, Psychosis, and Inappropriate Secretion of Antidiuretic Hormone

Author Affiliations

From the Department of Psychiatry, University of Iowa College of Medicine (Drs Fowler and Kronfol); the Veterans Administration Hospital (Dr Fowler); and the University of Iowa College of Pharmacy (Dr Perry), Iowa City.

Arch Gen Psychiatry. 1977;34(9):1097-1099. doi:10.1001/archpsyc.1977.01770210111010

• A review of the literature and the three presented cases indicate that multiple factors are often involved in the development of water intoxication in the psychotic. Although the syndrome of inappropriate secretion of antidiuretic hormones (SIADH) is one of these factors, it is usually associated with other causes of the SIADH. Evidence is lacking that the SIADH is an essential feature of a psychotic illness.