October 1977

Evidence Against Involvement of Endorphins in Sexual Arousal and Orgasm in Man

Author Affiliations

From the Department of Pharmacology, Stanford University, and the Addiction Research Foundation, Palo Alto, Calif.

Arch Gen Psychiatry. 1977;34(10):1179-1180. doi:10.1001/archpsyc.1977.01770220061006

• In a double-blind study, intravenous injection of naloxone, at a dose sufficient to saturate the opiate (endorphin) receptors, had no effect on sexual arousal, penile erection, ejaculation, or orgasm in a human subject. Apparently, endorphins are not involved in these phenomena.