• Two groups of young rhesus monkeys were subjected to repetitive peer separations, a procedure that has been shown to produce depressivelike reactions in infant monkeys. Midway through the procedure one group was treated with the antidepressant imipramine hydrochloride, the other with a saline placebo. In comparison with placebo treatment, the imipramine treatment yielded significant behavioral improvement in a form and with a time course similar to that seen when the drug is given clinically to human depressives. We discuss the implications of the findings.
Suomi SJ, Seaman SF, Lewis JK, DeLizio RD, McKinney WT. Effects of Imipramine Treatment of Separation-Induced Social Disorders in Rhesus Monkeys. Arch Gen Psychiatry. 1978;35(3):321-325. doi:10.1001/archpsyc.1978.01770270071006