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July 1978

Standard and Long-Acting Depot Neuroleptics in Chronic SchizophrenicsAn 18-Month Open Multicentric Study

Author Affiliations

From the Department of Clinical Pharmacology, Faculté de Médecine Pitié-Salpére, Paris.

Arch Gen Psychiatry. 1978;35(7):893-897. doi:10.1001/archpsyc.1978.01770310099008

• The overall objective of this 18-month open study was to compare standard neuroleptics and long-acting depot neuroleptics following the current psychiatric practice in order to determine the best therapy. Thirty French psychiatrists from 15 different wards participated in this experiment. One hundred eighty-one chronic schizophrenic patients were randomly assigned to receive one of the following three treatments: standard neuroleptics, pipotiazine palmitate, or fluphenazine decanoate. Criteria used for evaluation were an overall clinical evaluation by a psychiatrist, a Brief Psychiatric Rating Scale, and a Nurse's Observation Scale for Inpatient Evaluation. No significant difference (P >.05) was observed between the three groups in drug effectiveness or tolerance.