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August 1978

Peptides and PsychoneuroendocrinologyA Perspective

Author Affiliations

From the Department of Psychiatry, Biological Sciences Research Center, and the Neurobiology Program, University of North Carolina School of Medicine, Chapel Hill.

Arch Gen Psychiatry. 1978;35(8):999-1010. doi:10.1001/archpsyc.1978.01770320093009

• Research indicates that brain peptides exert both behavioral and endocrinologic effects in humans and animals. This review summarizes the best known behavioral actions of four endogenous peptides: luteinizing hormone-releasing hormone (LHRH), adrenocorticotrophic hormone (ACTH), vasopressin, and angiotensin. The hypothalamic-releasing hormones play a role in modulating pituitary-end organ systems. Behavioral disorders may, in the future, be susceptible to formulation in terms of changes in brain peptides. Peptide research in psychiatry may be approached in several ways.