• After a brief inpatient hospitalization, 104 acute, young schizophrenics, stratified by premorbid adjustment, were randomly assigned to one of four aftercare conditions for a six-week controlled trial. Conditions involved one of two dose levels of fluphenazine enanthate (1 ml or 0.25 ml) and presence or absence of crisis-oriented family therapy.
Relapses during the six-week period and at six-month follow--up were least in patients who received both high-dose and family therapy (0%) and greatest (48%) in the low-dose-no therapy group. Brief Psychiatric Rating Scale symptom ratings disclosed a significant family therapy effect at six weeks that was sustained at six months only for therapy patients originally receiving the high drug dose. Numerous interactions were found between premorbid adjustment status and response to the two treatment conditions.
Goldstein MJ, Rodnick EH, Evans JR, May PRA, Steinberg MR. Drug and Family Therapy in the Aftercare of Acute Schizophrenics. Arch Gen Psychiatry. 1978;35(10):1169-1177. doi:10.1001/archpsyc.1978.01770340019001