[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.159.197.114. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
July 20, 1979

Asymmetry and Mood, Emergent Properties of Serotonin RegulationA Proposed Mechanism of Action of Lithium

Author Affiliations

From the Department of Psychiatry, University of California at San Diego, La Jolla.

Arch Gen Psychiatry. 1979;36(8):909-916. doi:10.1001/archpsyc.1979.01780080083019
Abstract

The purpose of this communication is to develop a model of the pathogenesis of affective spectrum disorders and their treatment and prevention with lithium; the model is based on (1) studies of baseline and drug-induced bilateral asymmetry in tryptophan and serotonin levels in rat brain mesostriatal and mesolimbic systems, (2) singlecell quantitative histochemical determinations of serotonin content in lateral median and dorsal raphe nuclei, (3) the responses of brain tryptophan hydroxylase activity to psychotropic agents, (4) in vitro studies of the kinetic properties of tryptophan hydroxylase, and (5) evidence of lateral affective specialization in human brain. The disorders are construed as diseases of regulation involving an abnormal form of brain tryptophan hydroxylase with hyperbolic substrate kinetics, possibly resulting from a hereditary defect in enzyme cooperativity or calcium metabolism or the influence of yet unidentified ligands. The abnormal enzyme kinetics would serve to amplify the functional impact of existing bilateral asymmetries

First Page Preview View Large
First page PDF preview
First page PDF preview
×