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October 1979

The Psychological Treatment of DepressionEvidence for the Efficacy of Psychotherapy Alone, in Comparison With, and in Combination With Pharmacotherapy

Author Affiliations

From the Departments of Psychiatry and Epidemiology, Yale University School of Medicine, and the Depression Research Unit, Connecticut Mental Health Center, New Haven.

Arch Gen Psychiatry. 1979;36(11):1261-1269. doi:10.1001/archpsyc.1979.01780110115014

• Seventeen clinical trials are identified that test the efficacy of various psychological treatments (behavioral, cognitive, group, marital, interpersonal) alone, in comparison with, and in combination with pharmacotherapy in homogeneous samples of depressed outpatients. I describe the results of these studies, gaps in the evidence, and suggestions for future research directions.