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Article
December 1979

Color Blindness Not Closely Linked to Bipolar IllnessReport of a New Pedigree Series

Author Affiliations

From the Section on Psychogenetics, Biological Psychiatry Branch, National Institute of Mental Health, Bethesda, Md (Drs Gershon, Targum, and Bunney), and the Mailman Research Laboratories, McLean Hospital, Harvard Medical School, Belmont, Mass (Dr Matthysse).

Arch Gen Psychiatry. 1979;36(13):1423-1430. doi:10.1001/archpsyc.1979.01780130041005
Abstract

• A new pedigree series of bipolar manic-depressive patients admitted to the National Institute of Mental Health intramural research program was evaluated for linkage between bipolar illness and red-green color blindness, since previous studies had indicated that close linkage was generally present. Using family study methods, six informative pedigrees were investigated. Analysis was performed using a multigenerational procedure and taking into account variable penetrance. Close linkage could be definitively ruled out as a general finding. Bipolar and related illnesses are thus not generally transmitted by a single major gene close to the protan/deutan region of the human X-chromosome.

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