December 1979

Color Blindness Linkage to Bipolar Manic-Depressive IllnessNew Evidence

Author Affiliations

From the Department of Psychiatry, University Hospital Erasme, Free University of Brussels (Drs Mendlewicz and Linkowski), the National Institute of Mental Health, Bethesda, Md (Ms Guroff), and the Department of Psychiatry, State University of Utrecht, The Netherlands (Dr Van Praag).

Arch Gen Psychiatry. 1979;36(13):1442-1447. doi:10.1001/archpsyc.1979.01780130060007

• Linkage between protanopia and deuteranopia and bipolar manic-depressive illness is demonstrated in a sample of eight informative families ascertained in Brussels. Genetic heterogeneity of bipolar affective disorders is also shown in the present sutdy. These results add new evidence to the hypothesis of X-linked dominant genetic transmission of affective liability in a subgroup of patients with bipolar affective disorders.