[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
May 1980

Amitriptyline Once Daily vs Three Times Daily in Depressed Outpatients

Author Affiliations

From the Department of Psychiatry, University of Pennsylvania, Philadelphia.

Arch Gen Psychiatry. 1980;37(5):555-560. doi:10.1001/archpsyc.1980.01780180069007

• Two dosage schedules of amitriptyline hydrochloride, once daily vs three times daily, were compared in a group of 124 nonpsychotic depressed outpatients. After four weeks of treatment, patients on the once daily schedule had improved significantly more than patients receiving multiple doses on both physician and patient measures. The two groups did not differ in their attrition rates nor in reporting of side effects. Since treatment response to the tricyclic antidepressants is often delayed, once-daily dosage seems to offer a distinct advantage over more conventional multiple doses in depressed outpatients.