July 1980

Platelet Monoamine Oxidase Activity and the Classification of Depression

Author Affiliations

From the Department of Psychiatry, Duke University Medical Center, Durham, NC (Drs Davidson and McLeod); the John Umstead Hospital, Butner, NC (Drs Davidson and McLeod); the Department of Biostatistics, University of North Carolina, Chapel Hill (Dr Turnbull and Mr Feuer); and the Wellcome Research Laboratories, Research Triangle Park, NC (Dr White). Dr McLeod is now in private practice in Chapel Hill, NC.

Arch Gen Psychiatry. 1980;37(7):771-773. doi:10.1001/archpsyc.1980.01780200049005

• An attempt was made to compare platelet monoamine oxidase (MAO) activity in descriptively based types of nonbipolar depression. Platelet MAO activity was significantly higher in depression secondary to chronic anxiety, compared with primary unipolar depression and depression secondary to borderline personality, and in women compared with men. No significant differences were observed between endogenous-nonendogenous, delusional-nondelusional, psychomotor states, or different age groups.