August 1980

Pemoline, Methylphenidate, and Placebo in Children With Minimal Brain Dysfunction

Author Affiliations

From the Department of Psychiatry, Children's Hospital National Medical Center, Washington, DC (Dr Conners), and the Department of Child and Adolescent Psychiatry, Institute of Psychiatry, The Bethlem Royal Hospital and Maudsley Hospital, London (Dr Taylor).

Arch Gen Psychiatry. 1980;37(8):922-930. doi:10.1001/archpsyc.1980.01780210080009

• An eight-week double-blind comparison between pemoline (Cylert), methylphenidate (Ritalin) hydrochloride, and placebo was carried out on 60 hyperactive children. Measurements of home, school, achievement, cognitive function, and global clinical status were made at baseline, midtreatment, end of treatment, and posttreatment. Both drugs produced improvement in all areas except the achievement measures. One major difference between drugs was the apparently longer action of pemoline, since its effects at home and school tended to persist when the drug was withdrawn, whereas the patients receiving methylphenidate tended to regress to their baseline levels.