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Article
October 1980

Aberrant Monoamine Metabolite Levels in CSF and Family History of SchizophreniaTheir Relationships in Schizophrenic Patients

Author Affiliations

From the Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Hospital, Stockholm (Dr Sedvall); and the Department of Psychiatry, St Göran's Hospital, Karolinska Institute, Stockholm (Dr Wode-Helgodt).

Arch Gen Psychiatry. 1980;37(10):1113-1116. doi:10.1001/archpsyc.1980.01780230031004
Abstract

• In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition.

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