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November 1980

Clomipramine and Doxepin in Depressive NeurosisPlasma Levels and Therapeutic Response

Author Affiliations

From the Departments of Psychiatry and Pharmacology, Duke University Medical Center, Durham, NC (Dr Linnoila and Mr Skinner); the Department of Pharmacology, University of Helsinki, (Drs Linnoila, Seppala, and Mattila); and the Department of Clinical Chemistry, University of Oulu, Oulu, Finland (Drs Vihko and Pakarinen).

Arch Gen Psychiatry. 1980;37(11):1295-1299. doi:10.1001/archpsyc.1980.01780240093011

• The therapeutic efficacy, plasma levels, and psychomotor effects of tryptophan (L-tryptophan), clomipramine hydrochloride, and doxepin were investigated in "neurotically" depressed outpatients. The tricyclic antidepressants were significantly more efficacious than tryptophan in inducing remission. The alleviation of depression was preceded by an improvement of the initially slow information-processing rates in the depressed patients. The plasma levels of the tricyclics that were associated with a therapeutic response were significantly lower than those reported in "endogenously" depressed inpatients.