June 1981

Brain Monoamine Oxidase Activity in Schizophrenics and Controls

Author Affiliations

From Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Maternity Hospital, London (Drs Reveley, Glover, and Sandler); and the Medical Research Council Neurochemical Pharmacology Unit, University of Cambridge, England (Dr Spokes). Dr Reveley is now with the Institute of Psychiatry, London.

Arch Gen Psychiatry. 1981;38(6):663-665. doi:10.1001/archpsyc.1981.01780310063006

• Postmortem samples of caudate nucleus and frontal cortex from schizophrenic, schizophrenic-like, and control subjects were examined for monoamine oxidase activity using dopamine, phenylethylamine, and 5-hydroxytryptamine as substrates. There were no significant differences between the diagnostic groups with any of the three substrates. Neither was there a difference between the sexes, nor a consistent relationship of enzyme activity to age.