• Two studies compared propoxyphene napsylate (Darvon-N) with methadone hydrochloride as maintenance treatment for narcotic addicts. Most measures indicated that methadone was more effective than propoxyphene as a maintenance drug. Patients receiving propoxyphene reported more withdrawalrelated symptoms early in treatment, tended to drop out sooner than patients receiving methadone, and were more likely to abuse heroin. Nevertheless, follow-up interviews at one and six months after treatment indicated no between-group differences in adjustment.
Woody GE, Mintz J, Tennant F, O'Brien CP, McLellan AT, Marcovici M. Propoxyphene for Maintenance Treatment of Narcotic Addiction. Arch Gen Psychiatry. 1981;38(8):898-900. doi:10.1001/archpsyc.1981.01780330056005