August 1981

Propoxyphene for Maintenance Treatment of Narcotic Addiction

Author Affiliations

From the Veterans Administration Medical Center and the Department of Psychiatry, University of Pennsylvania, Philadelphia (Drs Woody, O'Brien, McLellan, and Marcovici); and the Department of Psychiatry (Dr Mintz) and the School of Public Health (Dr Tennant), University of California, Los Angeles.

Arch Gen Psychiatry. 1981;38(8):898-900. doi:10.1001/archpsyc.1981.01780330056005

• Two studies compared propoxyphene napsylate (Darvon-N) with methadone hydrochloride as maintenance treatment for narcotic addicts. Most measures indicated that methadone was more effective than propoxyphene as a maintenance drug. Patients receiving propoxyphene reported more withdrawalrelated symptoms early in treatment, tended to drop out sooner than patients receiving methadone, and were more likely to abuse heroin. Nevertheless, follow-up interviews at one and six months after treatment indicated no between-group differences in adjustment.