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September 1981

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of SchizophreniaI. The Relationship Between Anxiety Disorder and Schizophrenia

Author Affiliations

From the Department of Psychiatry and the Schizophrenia Biological Research Center, Bronx Veterans Administration Medical Center, Mt Sinai School of Medicine, Bronx, NY (Dr Kendler); the Connecticut Mental Health Center, New Haven (Dr Gruenberg); and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Drs Gruenberg and Strauss).

Arch Gen Psychiatry. 1981;38(9):973-977. doi:10.1001/archpsyc.1981.01780340025002

• Familial factors have been shown to be important in the transmission of both anxiety disorder and schizophrenia. The familial relationship between these two disorders, however, has received little attention. This study examines the relationship between anxiety disorder and schizophrenia by a blind independent analysis of the interviews from the Danish Adoption Study of Schizophrenia using DSM-Ill criteria. The results show neither a genetic nor a familial-environmental link between the two disorders. These results are not consistent with the unitary hypothesis of mental illness. From a genetic and familial-environmental perspective, anxiety disorder and schizophrenia appear to be distinct, unrelated psychiatric illnesses.