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Article
October 1981

Dementia of the Alzheimer TypeClinical Genetics, Natural History, and Associated Conditions

Author Affiliations

From the Department of Psychiatry, Psychiatry Research Unit (Dr Heston and Ms White); the Division of Neuropathology, Department of Laboratory Medicine and Pathology (Dr Mastri); and the Dight Institute for Human Genetics (Dr Anderson), University of Minnesota, Minneapolis.

Arch Gen Psychiatry. 1981;38(10):1085-1090. doi:10.1001/archpsyc.1981.01780350019001
Abstract

• Relatives of 125 probands, who had dementia of the Alzheimer type as proved by autopsy, were subjects of a genetic investigation. The relatives exhibited an excess of dementing illness consistent with genetic transmission. Risk to relatives decreased sharply as severity of the proband's illness decreased. Also, when compared with a control group and the general population, the relatives had excesses of Down's syndrome, lymphoma, and immune diatheses. These associated conditions also were more likely to be present when the proband had severe illness. Mortality at all ages was increased among the relatives.

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