January 1982

Stimulated Lymphocytes in Schizophrenia

Author Affiliations

From the Department of Anatomy, School of Medicine, Yamaguchi University, Ube, Japan (Dr Hirata-Hibi); Himeji Central Hospital, Himeji, Japan (Dr Higashi); and the Department of Immunology, Research Institute for Tuberculosis and Cancer, Tohoku University, Sendai, Japan (Drs Tachibana and Watanabe).

Arch Gen Psychiatry. 1982;39(1):82-87. doi:10.1001/archpsyc.1982.04290010058011

• This study examines the effect of neuroleptic medication on the distribution of the reported atypical lymphocytes of schizophrenia. The predominant atypical type in schizophrenia was termed the P-type atypical lymphocyte to differentiate the cell from other types of peripheral lymphocytes. Such P cells showed stimulated features: clear cytoplasmic basophilia and an irregularly shaped nucleus with a leptochromatic structure and occasionally one or two nucleoli, but the cell size ranged from small to large. P cells were found in all 42 schizophrenic patients examined and ranged from 5% to 45% of lymphocytes. Patients receiving neuroleptic medication had a lower mean percentage of P cells (17.8%) compared with patients not receivingneuroleptic medication (28.7%). The findings indicate that neuroleptic medication is not likely to be inducing the P-cell reaction.