February 1982

Growth Hormone Response to Dextroamphetamine in Depressed Patients and Normal Subjects

Author Affiliations

From the New York Psychiatric Institute and the Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York. Dr Halbreich is now with the Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Hospital and Medical Center, Bronx, NY.

Arch Gen Psychiatry. 1982;39(2):189-192. doi:10.1001/archpsyc.1982.04290020047009

• The human growth hormone (HGH) response to dextroamphetamine sulfate (doses, 0.1 and 0.15 mg/kg) was determined in both the morning and evening in patients with endogenous and atypical depression and in normal young men and normal postmenopausal women. Although the HGH response was found to be reduced in endogenously depressed postmenopausal women, it was equally reduced in normal postmenopausal women and in patients with atypical depression. Depressed and normal men had larger HGH responses, but there were no differences between depressed and normal men. These results do not confirm an earlier report that the reduced HGH response to dextroamphetamine is specific to endogenous depression. The results do suggest the importance to control for other variables in studies of HGH responses in psychiatric patients.