[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.129.96. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
June 1982

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of SchizophreniaIV. The Relationship Between Major Depressive Disorder and Schizophrenia

Author Affiliations

From the Department of Psychiatry and Schizophrenia Biological Research Center, Bronx Veterans Administration Medical Center, Mt Sinai School of Medicine, Bronx, NY (Dr Kendler); the Connecticut Mental Health Center (Dr Gruenberg), and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Drs Gruenberg and Strauss).

Arch Gen Psychiatry. 1982;39(6):639-642. doi:10.1001/archpsyc.1982.04290060001001
Abstract

• Genetic investigations offer one approach at evaluating the validity of Kraepelin's division of the functional psychoses into two major groups, schizophrenia and affective illness. In this study, DSM-III criteria for major depressive disorder (MDD) were blindly applied to the interviews with relatives from the Copenhagen sample of the Danish Adoption Study of Schizophrenia. No significant difference was found in the prevalence of MDD in the biological relatives of the control adoptees and the biological relatives of all the schizophrenic or only the chronic schizophrenic adoptees. Furthermore, no difference in the prevalence of MDD was found in the adoptive relatives of the schizophrenics and control subjects. These results support neither a genetic nor a familial-environmental link between schizophrenia and MDD and support the validity of the diagnostic division between them established by Kraepelin.

×