June 1982

Plasma Prolactin Concentrations and Psychopathology in Chronic Schizophrenia

Author Affiliations

From the Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, St Elizabeths Hospital (Drs Kleinman, Weinberger, Bigelow, Gillin, and Wyatt), the Department of Psychiatry, George Washington University, Washington, DC (Ms Klein), and the Departments of Pediatrics and Pharmacology, University of Virginia Medical Center, Charlottesville (Dr Rogol).

Arch Gen Psychiatry. 1982;39(6):655-657. doi:10.1001/archpsyc.1982.04290060017004

• Plasma prolactin concentrations in 17 drug-free chronic schizophrenic patients correlated inversely with ratings of their psychopathology. An inverse relationship between psychotic symptoms and plasma prolactin concentrations was particularly clear in patients with normal cerebral ventricular size as determined by computed tomography. The psychosis-prolactin relationship did not hold for schizophrenic patients with large ventricular size. These data suggest that the degree of psychosis is related to dopaminergic activity insofar as this is reflected by plasma prolactin concentrations, especially in schizophrenic patients with normal ventricular size. These findings lend further support to the hypothesis that ventricular size is a meaningful factor in subtyping chronic schizophrenic patients.