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February 1983

Increased Plasma MHPG in Dexamethasone-Resistant Depressed Patients

Author Affiliations

From the Laboratory of Clinical Science (Drs Jimerson and Kopin) and the Clinical Neuropharmacology Branch (Dr Insel), National Institute of Mental Health, Bethesda, Md, and the Department of Psychiatry, Langley Porter Neuropsychiatric Institute, University of California, San Francisco (Dr Reus).

Arch Gen Psychiatry. 1983;40(2):173-176. doi:10.1001/archpsyc.1983.01790020067006

• Severely depressed patients frequently show inadequate suppression of serum cortisol levels by dexamethasone. In a study of 15 depressed patients, we found a robust correlation between plasma levels of cortisol and 3-methoxy-4-hydroxyphenylglycol after dexamethasone administration. These results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.