• Severely depressed patients frequently show inadequate suppression of serum cortisol levels by dexamethasone. In a study of 15 depressed patients, we found a robust correlation between plasma levels of cortisol and 3-methoxy-4-hydroxyphenylglycol after dexamethasone administration. These results suggest that dexamethasone resistance and adrenergic activation reflect parallel responses to illness-related stress in some depressed patients.
Jimerson DC, Insel TR, Reus VI, Kopin IJ. Increased Plasma MHPG in Dexamethasone-Resistant Depressed Patients. Arch Gen Psychiatry. 1983;40(2):173-176. doi:10.1001/archpsyc.1983.01790020067006