• The sleep of 28 fully recovered, drug-free, prepubertal patients with major depressive disorder was recorded for three consecutive nights in the laboratory. Recovered depressives had significantly shorter first rapid eye movement period (REMP) latencies and a higher number of REMPs compared with themselves when depressed and with nondepressed neurotic and normal children. In addition, most sleep continuity measures improved considerably on recovery. We suggest that a short first REMP latency may be a marker of past episode or of trait in prepubertal major depressives.
Puig-Antich J, Goetz R, Hanlon C, Tabrizi MA, Davies M, Weitzman ED. Sleep Architecture and REM Sleep Measures in Prepubertal Major DepressivesStudies During Recovery From the Depressive Episode in a Drug-Free State. Arch Gen Psychiatry. 1983;40(2):187-192. doi:10.1001/archpsyc.1983.01790020085008