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July 1983

Altered P300 Topography in Schizophrenia

Author Affiliations

From the Department of Psychiatry, Massachusetts Mental Health Center (Drs Morstyn and McCarley), the Department of Neurology, Children's Hospital Medical Center (Dr Duffy), and Harvard Medical School (Drs Morstyn, Duffy, and McCarley), Boston.

Arch Gen Psychiatry. 1983;40(7):729-734. doi:10.1001/archpsyc.1983.01790060027003

• The spatiotemporal evolution of the P300 waveform was topographically mapped in a group of ten male chronic schizophrenics, using the technique of brain electrical activity mapping. Group-average P300 waveforms were constructed for the schizophrenic group and a group of matched controls. The control group's P300 showed a concentric development about a maximum in the centroparietal area, slightly displaced toward the left. In contrast, the schizophrenic group's P300 maximum was more anterior and to the right, with a deficiency in left temporal activity. Using the technique of significance probability mapping, it was demonstrated that the maximum between-group difference was localized to the left-middle and posterior temporal regions, where the schizophrenic group was deficient in activity.