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Dr Reus suggested that medication may have constituted a confounding factor in research design, pointing out that cognitive measures may be sensitive to medications and suggesting that the sample size was too small to afford an adequate test of within-group medication effects on performance. Although it is true that the sample sizes were too small to allow a statistically powerful test of medication effects, this issue was not pursued because it was not perceived as salient to the general thesis of the article. Consistent with previous reports that phenothiazines improve attentional performance, I found a nonsignificant trend toward superior performance for medicated patients on the CPT. However, the proportions of medicated patients within each diagnostic group were comparable. And, most important, the majority of medicated patients in the schizophrenic and schizoaffective groups were receiving antipsychotics in standard doses (11 in each group, to be exact). As stated in the article,
Walker E. Cognitive Changes in Schizoaffective Patients-Reply. Arch Gen Psychiatry. 1983;40(11):1255. doi:10.1001/archpsyc.1983.01790100101015