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May 1984

Lymphocyte Function in Major Depressive Disorder

Author Affiliations

From the Howard Mack Laboratory, Department of Psychiatry, Mount Sinai School of Medicine of the City University of New York.

Arch Gen Psychiatry. 1984;41(5):484-486. doi:10.1001/archpsyc.1984.01790160070008

Lymphocyte stimulation by phytohemagglutinin, concanavalin A, and pokeweed mitogen was significantly lower in a group of hospitalized depressed patients than in matched controls. The absolute number of T and B cells was lower in the depressed group, but the percentage of these cell types did not differ between the groups. These findings may be related to the altered neuroendocrine function found in patients with depressive disorders.