August 1985

Institutional Rearing and Diagnostic Outcome in Children of Schizophrenic MothersA Prospective High-Risk Study

Author Affiliations

From the Psykologisk Institut, University Department of Psychiatry, Kommunehospitalet, Copenhagen (Drs Parnas and Teasdale); and the Institute of Clinical Psychology, University of Copenhagen (Ms Schulsinger).

Arch Gen Psychiatry. 1985;42(8):762-769. doi:10.1001/archpsyc.1985.01790310024003

• Within a prospective, longitudinal study of offspring of schizophrenic mothers (so-called high-risk children), diagnostic outcome (schizophrenia, "schizotypal" personality disorder, other diagnoses, and no mental illness) was predicted by the mother's age at first hospitalization and by institutionalization during the first five years of life. Institutionalization was unrelated to adult psychopathology in a low-risk control group. These results are interpreted as supporting a diathesis-stress model of schizophrenic origin.