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Article
August 1985

Psychiatric Illness in First-degree Relatives of Schizophrenic and Surgical Control PatientsA Family Study Using DSM-III Criteria

Author Affiliations

From the Departments of Psychiatry and Human Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond (Dr Kendler); Yale Psychiatric Institute and Department of Psychiatry, Yale University School of Medicine, New Haven, Conn (Dr Gruenberg); the Psychiatric Epidemiology Research Unit, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown University, Providence, RI (Dr Tsuang). Dr Tsuang is now with the Section of Psychiatric Epidemiology and Genetics, Massachusetts Mental Health Center, the Department of Psychiatry, Harvard Medical School, and the Psychiatry Service, Brockton West Roxbury Veterans Administration Medical Center, Brockton, Mass.

Arch Gen Psychiatry. 1985;42(8):770-779. doi:10.1001/archpsyc.1985.01790310032004
Abstract

• This report examines the risk for psychiatric illness in 723 first-degree relatives of schizophrenics and 1,056 first-degree relatives of matched surgical control patients. Diagnoses in patients and relatives were made "blind" to one another, using DSM-III criteria. Information on relatives was obtained from personal interview and/or hospital records. Results were analyzed using two levels of diagnostic certainty and with or without relatives on whom only hospital records were obtained. In all analyses, the risk for schizophrenia was significantly greater (at least 18-fold) in the relatives of schizophrenics v controls. Evidence was also found for an increased risk in relatives of schizophrenics for schizoaffective disorder, paranoid disorder, and atypical psychosis but not for unipolar disorder, anxiety disorder, or alcoholism. As defined by DSM-III, schizophrenia is a familial disorder; however, the increased risk for psychotic illness in relatives of schizophrenics does not appear to be confined to schizophrenia alone.

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