• The short-term, dose-response effects of methylphenidate hydrochloride were evaluated on academic and social classroom measures in 29 children with attention deficit disorder. In a double-blind, cross-over design with order randomized, children received a placebo for two weeks and three doses of methylphenidate hydrochloride (0.15 mg/kg, 0.3 mg/kg, and 0.6 mg/kg) for one week each. Dependent measures included the output and accuracy of performance in grade-appropriate reading comprehension workbooks and arithmetic problems, spelling word acquisition, and observations of disruptive and on-task behavior. Beneficial drug effects and linear dose-response curves on all dependent measures were found. The results suggest that beneficial methylphenidate effects on classroom behavior may be accompanied by enhanced academic achievement in some hyperactive children.
Pelham WE, Bender ME, Caddell J, Booth S, Moorer SH. Methylphenidate and Children With Attention Deficit DisorderDose Effects on Classroom Academic and Social Behavior. Arch Gen Psychiatry. 1985;42(10):948-952. doi:10.1001/archpsyc.1985.01790330028003