• Nineteen children (mean [±SD] age, 14.5±2.3 years) with severe, primary obsessive-compulsive disorder completed a ten-week, double-blind, controlled trial of clomipramine hydrochloride (mean dosage, 141 mg/day) or placebo, each of which was administered for five weeks. Half of the subjects had not responded to previous treatment with other tricyclic antidepressants. There was a significant improvement in observed and self-reported obsessions and compulsions that was independent of the presence of depressive symptoms at baseline. Improvement in obsessive-compulsive symptoms did not correlate significantly with plasma concentrations of the drug or its metabolites. Clomipramine appears to be effective in the treatment of children with obsessive-compulsive disorder and the treatment seems to be independent of an antidepressant effect.
Flament MF, Rapoport JL, Berg CJ, Sceery W, Kilts C, Mellström B, Linnoila M. Clomipramine Treatment of Childhood Obsessive-Compulsive DisorderA Double-blind Controlled Study. Arch Gen Psychiatry. 1985;42(10):977-983. doi:10.1001/archpsyc.1985.01790330057007