February 1986

Abstinence Symptomatology and Psychiatric Diagnosis in Cocaine AbusersClinical Observations

Author Affiliations

From the Departments of Pharmacology (Dr Gawin) and Psychiatry (Drs Gawin and Kleber), and the Drug Dependence Unit, Connecticut Mental Health Center and the APT Foundation (Drs Gawin and Kleber), Yale University School of Medicine, New Haven.

Arch Gen Psychiatry. 1986;43(2):107-113. doi:10.1001/archpsyc.1986.01800020013003

• Abstinence symptoms and psychiatric diagnoses were evaluated in 30 chronic cocaine abusers. Structured diagnostic interviews were done within an experimental design intended to maximize differentiation of enduring symptoms from symptoms linked to binges of cocaine use. Longitudinal evaluations showed a three-phase sequence of post—cocaine abuse abstinence symptoms. Over half the sample also met criteria for ed 3 DSM-III, axis I psychiatric disorders. The findings present specific implications for treatment design.