• Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized.
Nasrallah HA, Olson SC, McCalley-Whitters M, Chapman S, Jacoby CG. Cerebral Ventricular Enlargement in SchizophreniaA Preliminary Follow-up Study. Arch Gen Psychiatry. 1986;43(2):157-159. doi:10.1001/archpsyc.1986.01800020067008