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September 1986

Response of Thyrotropin to Thyrotropin-Releasing Hormone as Predictor of Treatment OutcomePrediction of Recovery and Relapse in Treatment With Antidepressants and Neuroleptics

Author Affiliations

From the Psychobiological Research Unit, Department of Psychiatry, University of Vienna.

Arch Gen Psychiatry. 1986;43(9):861-868. doi:10.1001/archpsyc.1986.01800090047007

• We determined whether the response of thyrotropin (TSH) to thyrotropin-releasing hormone could predict the outcome of treatment with antidepressant and neuroleptic drugs. We studied 114 female patients diagnosed as having major and minor depressive, manic, schizoaffective, and schizophrenic disorders. A blunted TSH response (<5 μU/mL [<5 mU/L]) at admission was associated with recovery after nine weeks of inpatient treatment using clomipramine hydrochloride for depression and haloperidol for psychosis. A blunted TSH response at discharge was associated with early relapse in depressives receiving clomipramine maintenance therapy. Our findings support the notion that the thyrotropin-releasing hormone test is a "state" marker that may be of use in predicting the outcome of treatment with antidepressant and neuroleptic drugs.