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Article
January 1987

Nongenetic Factors in Gilles de la Tourette's Syndrome

Author Affiliations

Child Study Center, Childrens' Clinical Research Center, Departments of Psychiatry and Pediatrics Yale University School of Medicine PO Box 3333 New Haven, CT 06510
Departments of Psychology and Psychiatry University of Pennsylvania Philadelphia, PA 19104
Child Study Center and Department of Psychiatry Yale University School of Medicine
Child Study Center Yale University School of Medicine
Child Study Center and Department of Human Genetics Yale University School of Medicine
Child Study Center, Children's Clinical Research Center, Departments of Psychiatry and Pediatrics Yale University School of Medicine

Arch Gen Psychiatry. 1987;44(1):100. doi:10.1001/archpsyc.1987.01800130112025
Abstract

To the Editor.—  Interest in a possible hereditary component in the transmission and expression of Gilles de la Tourette's syndrome (TS) is longstanding. Although no specific genetic mechanism has been identified, several studies have reported a pattern of transmission that is consistent with an incompletely penetrant autosomal gene (D.L.P., J.F.L., unpublished data, 1985).1-4 The importance of nongenetic factors has also recently been emphasized by a twin study of TS reported by Price et al5 in which seven (23%) of the 30 monozygotic pairs were fully discordant for TS.In preparing for a more extensive evaluation of these discordant twin pairs, we recently examined unpublished data from the original study and found that in each case the unaffected co-twin had a higher birth weight than the affected twin (Table). These data must be considered as preliminary, since detailed case histories of the twin pregnancies were not obtained as part

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