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Article
February 1987

Regional Brain Function in SchizophreniaI. A Positron Emission Tomography Study

Author Affiliations

From the Cerebrovascular Research Center (Drs R. E. Gur, Resnick, Alavi, R. C. Gur, Silver, Saykin, Chawluk, Kushner, Reivich and Dann), the Departments of Psychiatry (Drs R. E. Gur, Resnick, R. C. Gur, Caroff, and Saykin), Neurology (Drs R. E. Gur, Alavi, R. C. Gur, Chawluk, Kushner, and Reivich), and Radiology (Drs Alavi, Reivich and Dann), and the Philadelphia Veterans Administration Hospital (Dr Caroff), University of Pennsylvania, Philadelphia.

Arch Gen Psychiatry. 1987;44(2):119-125. doi:10.1001/archpsyc.1987.01800140021003
Abstract

• Local cerebral glucose metabolism was determined with 18-F-fluorodeoxyglucose using positron emission tomography in a sample of 12 unmedicated schizophrenics and 12 matched normal controls. The data were analyzed for absolute metabolic rates and region/whole-brain ratios using the cortical-subcortical, antero-posterior, and laterality dimensions. Lobar areas within cortical regions were also compared. Across groups, subcortical metabolism was higher than cortical metabolism. Patients had lower metabolism, cortically and subcortically, and a steeper subcortical to cortical gradient. Patients with higher scores on the Brief Psychiatric Rating Scale had higher absolute metabolism and higher left relative to right hemispheric metabolism than did patients with lesser severity. The results did not show "hypofrontality" in schizophrenia. These findings provide some support for cerebral dysfunction in schizophrenia and indicate the need for further examination of the cortical-subcortical dimension.

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