[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.205.176.107. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
April 1987

Situational Panic AttacksBehavioral, Physiologic, and Biochemical Characterization

Author Affiliations

From the Clinical Neuroscience Research Unit, Connecticut Mental Health Center, Department of Psychiatry (Drs Woods, Charney, and Heninger), and the Section on Cardiology, Department of Internal Medicine (Drs McPherson and Gradman), Yale University School of Medicine, New Haven, Conn; and the West Haven (Conn) Veterans Administration Hospital (Drs McPherson and Gradman).

Arch Gen Psychiatry. 1987;44(4):365-375. doi:10.1001/archpsyc.1987.01800160077010
Abstract

• To investigate the pathophysiology of nonpharmacologically induced panic attacks, 18 drug-free agoraphobic patients and 13 matched healthy subjects underwent structured exposure to phobic situations. Heart rate, blood pressure, and plasma free 3-methoxy-4-hydroxyphenylglycol (MHPG), cortisol, growth hormone, and prolactin levels were measured before, during, and after exposure. Fifteen patients experienced situational panic attacks during exposure. Panicking patients displayed significantly greater increases in heart rate but not blood pressure or plasma free MHPG or cortisol in comparison with the healthy subjects. Growth hormone and prolactin responses tended to be smaller in the patients. If brain noradrenergic hyperactivity occurs during situational panic attacks, it may be too brief or too restricted in regional localization to affect MHPG levels in plasma. Chronically recurrent attacks may cause an adaptation of neuroendocrine mechanisms activated by anxiety or stress.

×