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January 1988

Blood Gas Changes and Hypophosphatemia in Lactate-Induced Panic-Reply

Author Affiliations

Department of Psychiatry College of Physicians and Surgeons Columbia University New York, NY 10025

Arch Gen Psychiatry. 1988;45(1):96. doi:10.1001/archpsyc.1988.01800250112016

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In Reply.—  The commments of Drs Bass and Gardner and Drs Griez and Pols add useful interpretations to our article. The former correctly note that a large body of work already attests to the association between anxiety disorder and HV. The latter support our conclusion that hypophosphatemia in patients with PD is probably a marker for HV.What is most striking, however, is that the two comments are directly contradictory. Drs Bass and Gardner affirm that "we have shown that some patients with agoraphobia and PD spend large portions of the waking day in the hypocapnic range," while Drs Griez and Pols state that "patients with PD do not hyperventilate between their attacks.... This was the case in our series... supported by blood gas studies that we recently completed."I am inclined to agree with Drs Bass and Gardner, who add the important qualifier "some patients" to their statement. Our data

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