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February 1988

High Intercorrelations Among Urinary Outputs of Norepinephrine and Its Major MetabolitesA Replication in Depressed Patients and Controls

Author Affiliations

From the Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism (Drs Roy, Guthrie, and Linnoila); and the Adult Psychobiology (Dr Karoum) and Clinical Neuroscience (Dr Pickar) Branches, National Institute of Mental Health, Bethesda, Md.

Arch Gen Psychiatry. 1988;45(2):158-161. doi:10.1001/archpsyc.1988.01800260072009

• We examined the intercorrelations among urinary outputs of norepinephrine (NE) and its three major metabolites in unipolar depressed patients (n = 28) and normal controls (n = 24). Among the depressed patients, levels of NE correlated with normetanephrine (NM), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA), and VMA correlated with NM and MHPG. In the total group of depressed and control subjects (n = 52), the sum of NE and its major metabolites correlated with urinary outputs of NE, NM, MHPG, and VMA. These highly significant correlations among urinary outputs of NE and its major metabolites replicate a previous report of strong correlations among these same four urinary substances in a smaller group of depressed patients.