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March 1988

Relative Hypophosphatemia in Patients With Panic Disorder

Author Affiliations

Lafayette Clinic and Department of Psychiatry Wayne State University School of Medicine Detroit, MI 48201

Arch Gen Psychiatry. 1988;45(3):294-295. doi:10.1001/archpsyc.1988.01800270114017

To the Editor.—  In the November 1986 issue of the ARCHIVES, Gorman et al1 reported that a low inorganic phosphate level at baseline appeared to be associated with patients who panicked during the subsequent lactate infusion. They also reported a cutoff point of 0.73 mmol/L (2.25 mg/dL), below which a panic attack during the subsequent lactate infusion was virtually assured. Because this finding has important theoretical implications, we decided to check baseline inorganic phosphate level in relation to panic attacks during infusions in our patients and controls.We infused 86 patients who had panic disorder and 45 healthy controls with sodium lactate, isoproterenol hydrochloride, and dextrose hydrochloride. All patients

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