June 1988

A Comparison of Plasma Homovanillic Acid Concentrations in Schizophrenic Patients and Normal Controls

Author Affiliations

From the Department of Psychiatry, Mount Sinai School of Medicine, Bronx, NY, and the Bronx (NY) Veterans Administration Medical Center.

Arch Gen Psychiatry. 1988;45(6):561-563. doi:10.1001/archpsyc.1988.01800300057006

• Plasma homovanillic acid concentrations, a potential index of central dopamine turnover, were examined in normal control subjects and chronic schizophrenic patients over a 12hour period, including the period of sleep. Plasma homovanillic acid concentrations were lower in schizophrenic patients compared with normal controls at all times; however, within the group of schizophrenics, the more symptomatic patients had higher plasma homovanillic acid concentrations than the less severely ill patients. These data are consistent with a more complex role of dopamine in schizophrenia than was previously conceptualized.