• To test the possibility that some cases of schizophrenia result from infection with a transmissible slow viral agent, 57 experimental animals (six chimpanzees, 12 Old World monkeys, 17 New World monkeys, and 22 guinea pigs) were inoculated intracerebrally with brain tissue from ten patients and followed up for six years. Behavioral comparisons with control animals revealed no consistent behavioral differences. Histological, immunohistochemical, and morphometric examination of brains of animals that died revealed no specific neuropathological abnormalities. These findings do not support a role for a virus-induced slow infection in the pathogenesis of schizophrenia but must be weighed against methodological limitations in animal susceptibility, disease communicability, and assay sensitivity.
Kaufmann CA, Weinberger DR, Stevens JR, Asher DM, Kleinman JE, Sulima MP, Gibbs CJ, Gajdusek DC. Intracerebral Inoculation of Experimental Animals With Brain Tissue From Patients With SchizophreniaFailure to Observe Consistent or Specific Behavioral and Neuropathological Effects. Arch Gen Psychiatry. 1988;45(7):648-652. doi:10.1001/archpsyc.1988.01800310056007