August 1988

High Correlations of Norepinephrine, Dopamine, and Epinephrine and Their Major Metabolite Excretion Rates

Author Affiliations

From the Laboratory of Clinical Studies, DICBR, National Institute on Alcohol Abuse and Alcoholism (Drs Linnoila and Adinoff); and Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health (Dr Potter and Mr Oliver), Bethesda, Md.

Arch Gen Psychiatry. 1988;45(8):701-704. doi:10.1001/archpsyc.1988.01800320011001

• We have previously reported high correlations between norepinephrine and its metabolite outputs in depressed patients. In this article, we expand this finding to healthy volunteers and alcoholic patients. Furthermore, we find similar high correlations between urinary outputs of dopamine, norepinephrine, and their major metabolites. The same is true, to a lesser degree, for epinephrine and metanephrine outputs. There are implications of these findings for psychobiological research on the monoamine systems.