[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.175.236. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1989

Efficacy of Fluvoxamine in Obsessive-Compulsive DisorderA Double-blind Comparison With Placebo

Author Affiliations

From the Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Ribicoff Research Facilities, New Haven (Drs Goodman, Price, Delgado, Heninger, and Charney); and the Department of Psychiatry, Brown University School of Medicine, Butler Hospital, Providence, RI (Dr Rasmussen).

Arch Gen Psychiatry. 1989;46(1):36-44. doi:10.1001/archpsyc.1989.01810010038006
Abstract

• A six- to eight-week double-blind placebo-controlled trial of the potent and selective serotonin reuptake inhibitor fluvoxamine was conducted in 42 patients with primary obsessive-compulsive disorder (OCD). Approximately one half of the patients also had symptoms of major depression. Fluvoxamine was significantly better than placebo on all measures of obsessive-compulsive symptoms. Nine of 21 patients were responders ("much improved") with fluvoxamine compared with no responders with placebo, and fluvoxamine was effective in patients with OCD both with and without secondary depression. Response of OCD was not correlated with severity of baseline depression. These data lend partial support to the serotonin hypothesis of OCD. However, since a number of patients failed to respond to fluvoxamine, the role of other neurochemical systems in this disorder needs to be explored.

×