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Article
March 1989

Elevated Levels of Soluble Interleukin 2 Receptors in Schizophrenia

Author Affiliations

Clinical Neuroscience Branch National Institute of Mental Health Bldg 109, Room 4N-212 9000 Rockville Pike Bethesda, MD 20892
Immunophysiology Section Metabolism Branch National Cancer Institute Bldg 10, Room 4N-112 9000 Rockville Pike Bethesda, MD 20892
Clinical Neuroscience Branch National Institute of Mental Health Bldg 10, Room 4N-224 9000 Rockville Pike Bethesda, MD 20892

Arch Gen Psychiatry. 1989;46(3):291-292. doi:10.1001/archpsyc.1989.01810030097017
Abstract

To the Editor —  Immunologic factors have been implicated in both the cause Levels of soluble interleukin 2 (IL-2) receptor in the serum of schizophrenic patients and healthy controls. Soluble IL-2 receptors were measured by a sandwich enzymelinked immunosorbent assay as previously described.7 Each point represents the value for one subject; 1 U is approximately 3 pg of soluble IL-2 receptor. Schizophrenic patients (N = 30) were diagnosed using DSMIII and Research Diagnostic Criteria. The horizontal line indicates 2 SDs above the mean value for healthy controls; asterisk, P<.001 compared with controls (N =13) by Student's t test. and pathogenesis of schizophrenia, and alterations in immune measures, such as serum and cerebrospinal fluid immunoglobulin levels, circulating B and T lymphocytes, and the presence of anti—brain autoantibodies, have been reported by some but not all laboratories.1 Problems in demonstrating consistent immunologic stigmata in schizophrenia may

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